About John Manzetti

John Manzetti

John Manzetti is a visionary financial and business leader, technology entrepreneur, start-up advisor, investor and expert on the topics of economic development, venture capital formation and the commercialization of innovation. He is globally recognized for his prowess in taking innovation from “Concept to Commercialization TM” and market entry. He has led nearly $200 million in capital rounds and $1 billion in mergers and acquisitions during his career. As President and CEO of the Pittsburgh Life Sciences Greenhouse (PLSG) from 2006 through 2016, John and his team assisted nearly 500 companies, investing $22 million into 80 companies, which leveraged $1.5 billion of additional capital into the region. These companies brought over 135 products to market. John also founded the Accelerator Fund, LLC, the only pure life sciences venture capital fund in the region, focused on high-impact investments in healthcare companies.

John is also co-founder and business advisor for JTM, LLC, an activity-based, cost-comparison travel company initially focused on the cruise industry, but with applications that will span the entire travel industry in the future. And he is Business Advisor and Chief Administration Officer for SteelFusion Clinical Laboratory, LLC, a leader in oral fluid drug detection with three issued parents and with more on the way.

Prior to PLSG and Manzetti Group, John held the position of President and Chief Executive Officer at NOMOS Corporation, an innovative leader in the field of radiation therapy treatment solutions for solid cancer tumors. At NOMOS, under John’s leadership, the Company grew from a $4 million domestic operation to a $30 million global healthcare company, and led the company through the IPO process before selling to a public company in 2004.

Prior to NOMOS, John was Executive Vice President and Chief Financial Officer, Secretary and Treasurer of Carnegie Group, Inc., a leading artificial intelligence company spun out of Carnegie Mellon University. As CFO, John led the team of lawyers, accountants and investment bankers before presenting the company to investors in 22 cities in a global roadshow resulting in a successful IPO in 1995. John was also Executive Vice President and General Manager of the Government Business Unit and Manufacturing Business Unit, and directed more than 75 software systems developers. And, he also led the merger team that resulted in an acquisition by a publicly traded, international software and services company in 1998.

Before Carnegie Group, John was a senior financial executive at Babcock & Wilcox Company, a leader in the power generation equipment industry, where he progressed through the ranks in finance, directed manufacturing scheduling for five facilities with over 7,000 employees and later was Group Controller, managing operations for a $600 million global organization with six operating divisions and joint ventures on 4 continents.

In 2016, John received the Smart 50 Award by Smart Business Pittsburgh for his leadership of PLSG, and won the “Impact Award” for leading the organization having the most impact on regional economic growth. Also in 2016, John received the Pittsburgh Business Times Health Care Hero Award in recognition of his individual contributions to the regional healthcare community. In 2011, John was the recipient of the TechQuest Pennsylvania Outstanding Leadership in Technology Award. John was the winner of both the Ernst & Young Entrepreneur of the Year and the Carnegie Science Center Catalyst Award for the Life Sciences in 2008.

In 2018, John shared his financial knowledge with the world by releasing his first book, “Small Bites of the Elephant.” In the book, he tackles complex business topics, breaking them down for the average reader, that apply to both experienced corporate professionals to future entrepreneurs currently grinding away in the work force. Pulling from his wealth and knowledge, he shares his experiences and anecdotes in such a way as to teach and also entertain on the business of life.

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John has served as a Board Director and on committees at both public and private companies and for both for-profit and non-profit organizations. He is very active in the business community, serving in the capacities of business advisor, Board member and Board Chairman of several early-stage and growth-stage organizations.

He earned a Bachelor of Science in Business Administration from Geneva College and an MBA in Business Management from the University of Akron. John was also awarded an Honorary Doctorate of Entrepreneurial Business from Geneva College for his achievements in business.

John Manzetti Resume (.PDF)

Awards & Recognition

2016 Smart Business Pittsburgh “Impact Award” for leading the organization having the most impact on regional economic growth.

2016 Smart Business Pittsburgh “Smart 50” Recognition Award

2016 Smart Business Times Health Care Hero Award

2011 Honorary Doctorate in Business from Geneva College

2011 TechQuest Pennsylvania Outstanding Leadership in Technology

2008 Ernst & Young Entrepreneur of the Year Award

2008 Carnegie Science Center Catalyst Award for Life Sciences

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